Predicting Proteolysis-Targeting Chimeras' (PROTACs) ADME/Tox Properties

We have tested a small set of PROTACs against several human drug transporters in vitro as well as in zebrafish for their effects on embryo and larval mortality, morphology, embryo photomotor response, and larval photomotor response. We will report the preliminary outcomes of these combined assessments and discuss the implications for PROTACs development as well as how this data could be used for machine learning model generation and evaluation.